Lab News

Our latest paper out in Nature
In our newest paper we identify novel small-molecule inhibitors of POLRMT that also have anti-tumor effects. Congratulations to our former postdoc Brad Peter, and all our collaborators! Read more at Nature.

Grant from the Swedish Cancer Society
(20-11-2020) 6 million SEK awarded to Claes Gustafsson from the Swedish Cancer Society for a 3 year project on mitochondrial gene expression as a target for cancer therapy. Read more about it in a short interview with Claes in Akademiliv.

Our latest review on mtDNA replication is out
(12-10-2020) Access our new review at Crit Rev Biochem Mol Biol. We present the latest developments in mammalian mtDNA replication, and also discuss the mechanisms behind how mtDNA deletions are formed.

Bradley Peter moves to AstraZeneca
(29-04-2020) We sadly say goodbye today to our postdoc and structure expert, Brad Peter, who is starting a new position at AstraZeneca in Gothenburg.

Postdoc positions
(06-04-2020) We will be hiring postdocs! If you are interested, please send your CV to Jay Uhler.

Carlos Pardo Hernández completes his half-time seminar
(31-01-2020) Our REMIX PhD student Carlos made the cut with a great talk about his PhD work in front of colleagues and his two examiners. Congratulations!

National DNA Transactions Meeting
(29-01-2020) An inspiring start to the year at the National DNA Transactions meeting in Stockholm. Many excellent talks including from our REMIX PhD fellow Carlos Pardo Hernández.

See our latest paper in Molecular Cell
(04-10-2019) Our work on REXO2 is now out in Molecular Cell. Congratulations to our former postdoc Tom Nicholls and all our collaborators! 

Welcome Laleh Arabanian
(01-10-2019) Great to have Laleh Arabanian on board who joins the group as a researcher.

New paper on novel pathogenic mtSSB mutations 
(30-09-2019) Zsolt Szilagyi from our group contributed to a multi-group collaboration led by the Carelli and Pippucci groups that identifies novel mtSSB mutations in patients with optic atrophy spectrum disorder.

Brad gives talk at the Mitochondria in Human Disease Conference
(18-09-2019) Our postdoc Brad Peters gave a great talk and poster presentation about POLRMT disease-mutants at the Mitochondria in Human Disease Conference in beautiful Saltsjöbaden in Stockholm. Also presenting super talks and posters were our former PhD student Paulina Wanrooij and former postdoc Tom Nicholls, both now PI’s continuing in mtDNA/RNA research.

A paper out from our collaboration with the Larsson group
(01-05-2019) Congratulations to our PhD student (now postdoc at the Crick) Viktor Posse for his contribution to the characterization of the first TFEM knockout mouse. Published in EMBO ReportsTEFM regulates both transcription elongation and RNA processing in mitochondria.

New year, new paper – out in PLoS Genetics
(07-01-2019)  A new year all the happier with our latest paper by Viktor Posse and coauthors – RNase H1 directs origin-specific initiation of DNA replication in human mitochondria.

New paper out in Human Molecular Genetics
(03-12-2018) Congratulations to our postdoc Bradley Peter and PhD student Carlos Pardo Hernández on their latest paper out in HMG – a structural analysis of adPEO-related TWINKLE mutants.

Tom Nicholls starts his own group 
(02-11-2018) We say goodbye to our postdoc Tom Nicholls and wish him all the best as a new group leader at the Wellcome Trust Centre for Mitochondrial Research.

REMIX Meeting & Workshop in Gothenburg
(17-10-2018) The 2nd Annual REMIX Meeting was held in Gothenburg, 31 Oct – 1 Nov, for all REMIX PI’s and fellows. This was followed by a data analysis workshop for fellows from 1 – 4 Nov.

European Researchers’ Night
(28-09-2018) This year we visited a local Gothenburg high school and talked to pupils about being a researcher and why the study of mitochondria is important.

New review paper in Trends in Biochemical Sciences
(14-09-2018) In our latest review we examine the latest developments on how mtDNA is separated after DNA replication. Link to Trends Biochem Sci article here.

Grant awarded to Tom Nicholls
(01-06-2018) Congratulations to our postdoc Tom Nicholls who received a Wilhelm and Martina Lundgren Foundation grant.

2018 EMBO Workshop on Molecular Biology of Mitochondrial Gene Expression
(20-05-2018) Great assembly of over 100 scientists from all over the world in Svartsjö, Sweden for the biennual EMBO Workshop. From our group, Claes Gustafsson gave a seminar and Tom Nicholls presented a poster.

2018 International Science Festival in Gothenburg
(20-04-2018) High up in Gothenburg’s Ferris wheel, we welcomed visitors into our pod to talk about our research on mitochondrial DNA and its expression. Read more about the yearly International Science Festival in Gothenburg here.

9 million SEK from VR
(11-2017) Sahlgrenska Academy receives second largest country-wide funding from VR (the Swedish Research Council). Claes Gustafsson amongst top recipients with 9 million SEK over 5 years.

In-house seminar by Claes Gustafsson
(08-11-2017) The human mitochondrial genome and its expression. Medical Hill seminar series, Ivan Ivarsson lecture hall.

Welcome Carlos Pardo Hernándes
(10-2017) Carlos Pardo Hernández starts his PhD in our group. He is a fellow of the REMIX Innovative Training Network.

Grant from KAW
(28-10-2017) Claes Gustafsson among co-applicants to receive 34.5 million SEK from the Knut and Alice Wallenberg Foundation.

The KAW Foundation celebrates its 100 year anniversary with GU conference
(28-09-2017) The Knut and Alice Wallenberg Foundation celebrated its 100 year anniversary with a conference on Metabolism at Gothenburg University. Our postdoc Tom Nicholls and Prof. Doug Turnbull, Director of the Wellcome Trust Centre for Mitochondrial Research at Newcastle University, gave great back-to-back talks.

2017 International Science Festival in Gothenburg
(13-05-2017) This year we talked about mtDNA over Swedish fika at the Gothenburg Garden Society.  Read more about the yearly International Science Festival in Gothenburg here.

Viktor Posse successfully defends his PhD thesis
(01-2017) Congratulations to Viktor Posse who gave a great defence of his work on mitochondrial transcription.

REMIX Innovative Training Network launches
(2016) The REMIX training network is a four-year programme aimed at elucidating the molecular mechanisms and pathways that regulate mitochondrial gene expression. The Gustafsson lab will recruit one PhD student as part of the network.

2016 European Researchers’ Night
(30-9-2016) The Gothenburg Maritime Museum hosted this year’s European Researchers’ Night. Our group volunteered and brought along some fun props to show curious visitors how DNA is replicated.

Silver prize to Brad Peters for best poster at the 2016 EMBO Workshop
(15-05-2016) Congratulations to Brad Peters who won second best poster at the EMBO Workshop on Molecular Biology of Mitochondrial Gene Expression. This year the conference took place in Bro, Sweden, with over 100 researchers from all over the world.

Gabor Banyai completes his PhD 
(01-2016) Congratulations to Gabor Banyai who gave a great defence of his work on the Mediator complex.

Two eminent scholars join us for their sabbatical leave
(2015) Two scientists from the University of Newcastle – Prof. Zofia Chrzanowska-Lightowlers, Director of Neuroscience, and Prof. Robert Lightowlers, Director of ICaMB, start a six month sabbatical in our group.